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Third party human digestion in vitro trialUpdated 2 days ago

What does the science say about Biotic⁺?


Biotic⁺ is more than just a probiotic—it’s a carefully tested, science-backed formula designed to support gut and brain health. 

🔬 What kind of research was done?


To evaluate Biotic⁺, we worked with independent scientists from ProDigest using advanced and validated digestive simulation models (Simulator of the Human Microbial Ecosystem). In this study they compared the effectiveness of Biotic+ against 4 other market leading probiotics. The lab used the in vitro tools to replicate the conditions of the human gut, helping them measure:

  • Survival of probiotics through the digestive system

  • Impact on gut microbiota activity and composition

  • Production of beneficial compounds like short-chain fatty acids (SCFAs)


This study was peer-reviewed and published in Nutrients in 2024.


🔍 What did the study find?

The results were compelling—here’s what stood out:

✅ Proven survival to the gut

  • Biotic⁺ uses a delayed-release capsule and acid resistant strains designed to protect live cultures from harsh stomach acid and bile.

  • Over 50% of bacteria survived the journey to the colon—compared to less than 1% in the other leading brans who used liquid, powder, or standard capsules.

  • This means the live strains actually reach the part of your gut where they’re meant to work.

🌱 Positive shifts in the gut microbiome

  • Once in the colon, Biotic⁺ helped increase beneficial strains like Lactobacillus and Bifidobacterium.

  • It also supported the growth of other helpful bacteria like Roseburia, Faecalibacterium, and Coprococcus—all linked with anti-inflammatory and mood-supportive benefits.

🧪 Increased production of SCFAs

  • These are vital for gut barrier health, immune function, and reducing inflammation.

  • Biotic⁺ increased levels of acetate, butyrate, and propionate—all linked to benefits for gut, brain, and metabolic health.


🤔 Why does this matter?

The real magic of a probiotic happens after it survives digestion. With Biotic⁺, we’ve shown that:

  • You get viable, effective live bacteria where they matter most

  • It encourages a more diverse and resilient gut microbiome

  • It may help support digestion, immunity, mood, and overall wellbeing


🔎 Want to explore more?


You can dive deeper into the science here 👉 The Science of Biotic⁺
Or get in touch if you’d like a copy of the full published study—we’re always happy to share!


📚 Reference


Govaert et al. (2024). Survival of probiotic bacterial cells in the upper gastrointestinal tract and the effect of the surviving population on the colonic microbial community activity and composition. Nutrients, 16(16).

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